The gameplay is very similar to that of classics like Zombies Ate My Neighbors and Smash TV, with the difference that Night of the Cephalopods is a pretty short game. The number of levels is small and you only have one weapon, although it's more than enough to last the whole night.
The strongest point of the game is that you hear the character's narration in first person throughout the whole adventure, announcing how he's running out of ammo, telling you where exactly he is and what he thinks about the place you've just visited.
Night of the Cephalopods is a really fun action game. Besides offering a bit of novelty, it lets you use the Xbox 360 controllers, which is greatly appreciated in this type of game.